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| Unknown | 1992-06-06 | 192.1 KB |
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| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
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| Newton Package (archive/newtonPackage)
| ext
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| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
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| 100%
| file
| data
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hex view+--------+-------------------------+-------------------------+--------+--------+
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|00000550| 61 74 6f 72 79 20 4d 61 | 6e 61 67 65 6d 65 6e 74 |atory Ma|nagement|
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|00000780| 20 6d 6f 73 74 6c 79 20 | 61 66 66 65 63 74 73 20 | mostly |affects |
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|00002df0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 54 72 |--------|----..Tr|
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|00002e50| 65 20 4c 61 73 65 72 0d | 0a 0d 0a 54 61 6e 20 4f |e Laser.|...Tan O|
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|00002ed0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002ee0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|000043e0| 20 20 50 6e 65 75 6d 6f | 63 79 73 74 69 73 20 63 | Pneumo|cystis c|
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|000046a0| 65 75 6d 6f 6e 69 74 69 | 73 20 69 6e 20 68 61 6c |eumoniti|s in hal|
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|00004b30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00004c30| 39 38 38 0d 0a 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |988..---|--------|
|00004c40| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004c50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004c60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004c70| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004c80| 2d 2d 2d 0d 0a 0d 0a 41 | 62 73 74 72 61 63 74 0d |---....A|bstract.|
|00004c90| 0a 0d 0a 20 20 20 20 20 | 43 79 61 6e 6f 73 69 73 |... |Cyanosis|
|00004ca0| 20 61 6e 64 20 68 79 70 | 6f 78 69 61 20 61 72 65 | and hyp|oxia are|
|00004cb0| 20 77 65 6c 6c 2d 72 65 | 63 6f 67 6e 69 7a 65 64 | well-re|cognized|
|00004cc0| 20 6c 61 74 65 20 66 65 | 61 74 75 72 65 73 20 6f | late fe|atures o|
|00004cd0| 66 20 50 6e 65 75 6d 6f | 63 79 73 74 69 73 0d 0a |f Pneumo|cystis..|
|00004ce0| 63 61 72 69 6e 69 69 20 | 70 6e 65 75 6d 6f 6e 69 |carinii |pneumoni|
|00004cf0| 61 20 28 50 43 50 29 2e | 20 20 48 6f 77 65 76 65 |a (PCP).| Howeve|
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|00004d10| 20 77 69 74 68 20 73 79 | 6d 70 74 6f 6d 73 20 73 | with sy|mptoms s|
|00004d20| 75 67 67 65 73 74 69 76 | 65 20 6f 66 0d 0a 50 43 |uggestiv|e of..PC|
|00004d30| 50 20 68 61 76 65 20 6e | 6f 72 6d 61 6c 20 61 72 |P have n|ormal ar|
|00004d40| 74 65 72 69 61 6c 20 62 | 6c 6f 6f 64 20 67 61 73 |terial b|lood gas|
|00004d50| 20 76 61 6c 75 65 73 2e | 20 20 42 65 63 61 75 73 | values.| Becaus|
|00004d60| 65 20 6c 6f 77 20 61 72 | 74 65 72 69 61 6c 20 6f |e low ar|terial o|
|00004d70| 78 79 67 65 6e 0d 0a 70 | 72 65 73 73 75 72 65 20 |xygen..p|ressure |
|00004d80| 28 50 61 4f 32 29 20 69 | 73 20 61 73 73 6f 63 69 |(PaO2) i|s associ|
|00004d90| 61 74 65 64 20 77 69 74 | 68 20 68 69 67 68 20 6d |ated wit|h high m|
|00004da0| 6f 72 74 61 6c 69 74 79 | 20 69 6e 20 70 61 74 69 |ortality| in pati|
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|00004e00| 20 68 79 70 6f 78 69 63 | 20 61 74 20 72 65 73 74 | hypoxic| at rest|
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|00004e20| 72 76 69 76 61 6c 2e 0d | 0a 20 20 20 20 20 54 6f |rvival..|. To|
|00004e30| 20 64 65 74 65 72 6d 69 | 6e 65 20 77 68 65 74 68 | determi|ne wheth|
|00004e40| 65 72 20 50 43 50 20 63 | 61 6e 20 62 65 20 64 65 |er PCP c|an be de|
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|00004e60| 6c 6c 20 69 6e 20 69 74 | 73 20 65 61 72 6c 79 20 |ll in it|s early |
|00004e70| 70 68 61 73 65 0d 0a 62 | 79 20 74 68 65 20 64 65 |phase..b|y the de|
|00004e80| 67 72 65 65 20 6f 66 20 | 65 78 65 72 63 69 73 65 |gree of |exercise|
|00004e90| 2d 69 6e 64 75 63 65 64 | 20 6f 78 79 67 65 6e 20 |-induced| oxygen |
|00004ea0| 64 65 73 61 74 75 72 61 | 74 69 6f 6e 2c 20 61 72 |desatura|tion, ar|
|00004eb0| 74 65 72 69 61 6c 20 6f | 78 79 67 65 6e 0d 0a 73 |terial o|xygen..s|
|00004ec0| 61 74 75 72 61 74 69 6f | 6e 20 77 61 73 20 6d 65 |aturatio|n was me|
|00004ed0| 61 73 75 72 65 64 20 62 | 79 20 63 6f 6e 74 69 6e |asured b|y contin|
|00004ee0| 75 6f 75 73 20 70 75 6c | 73 65 20 6f 78 69 6d 65 |uous pul|se oxime|
|00004ef0| 74 72 79 20 61 66 74 65 | 72 20 31 30 20 6d 69 6e |try afte|r 10 min|
|00004f00| 75 74 65 73 20 6f 66 0d | 0a 65 78 65 72 63 69 73 |utes of.|.exercis|
|00004f10| 65 20 69 6e 20 31 36 20 | 70 61 74 69 65 6e 74 73 |e in 16 |patients|
|00004f20| 20 77 69 74 68 20 62 69 | 6f 70 73 79 2d 70 72 6f | with bi|opsy-pro|
|00004f30| 76 65 6e 20 50 43 50 20 | 61 6e 64 20 61 20 6c 6f |ven PCP |and a lo|
|00004f40| 77 20 72 65 73 74 69 6e | 67 20 50 61 4f 32 2c 20 |w restin|g PaO2, |
|00004f50| 32 34 0d 0a 70 61 74 69 | 65 6e 74 73 20 77 69 74 |24..pati|ents wit|
|00004f60| 68 20 62 69 6f 70 73 79 | 2d 70 72 6f 76 65 6e 20 |h biopsy|-proven |
|00004f70| 50 43 50 20 61 6e 64 20 | 61 20 6e 6f 72 6d 61 6c |PCP and |a normal|
|00004f80| 20 72 65 73 74 69 6e 67 | 20 50 61 4f 32 2c 20 31 | resting| PaO2, 1|
|00004f90| 39 20 70 61 74 69 65 6e | 74 73 20 77 69 74 68 0d |9 patien|ts with.|
|00004fa0| 0a 6f 74 68 65 72 20 63 | 68 65 73 74 20 64 69 73 |.other c|hest dis|
|00004fb0| 65 61 73 65 73 20 61 6e | 64 20 61 20 6e 6f 72 6d |eases an|d a norm|
|00004fc0| 61 6c 20 72 65 73 74 69 | 6e 67 20 50 61 4f 32 2c |al resti|ng PaO2,|
|00004fd0| 20 61 6e 64 20 31 32 20 | 68 65 61 6c 74 68 79 20 | and 12 |healthy |
|00004fe0| 61 67 65 2d 20 61 6e 64 | 0d 0a 73 65 78 2d 6d 61 |age- and|..sex-ma|
|00004ff0| 74 63 68 65 64 20 76 6f | 6c 75 6e 74 65 65 72 73 |tched vo|lunteers|
|00005000| 2e 0d 0a 20 20 20 20 20 | 49 6e 20 31 35 20 28 39 |... |In 15 (9|
|00005010| 34 25 29 20 6f 66 20 74 | 68 65 20 31 36 20 70 61 |4%) of t|he 16 pa|
|00005020| 74 69 65 6e 74 73 20 77 | 69 74 68 20 50 43 50 20 |tients w|ith PCP |
|00005030| 61 6e 64 20 61 20 6c 6f | 77 20 72 65 73 74 69 6e |and a lo|w restin|
|00005040| 67 20 50 61 4f 32 20 61 | 6e 64 20 69 6e 20 31 39 |g PaO2 a|nd in 19|
|00005050| 0d 0a 28 38 30 25 29 20 | 6f 66 20 74 68 65 20 32 |..(80%) |of the 2|
|00005060| 34 20 70 61 74 69 65 6e | 74 73 20 77 69 74 68 20 |4 patien|ts with |
|00005070| 50 43 50 20 61 6e 64 20 | 61 20 6e 6f 72 6d 61 6c |PCP and |a normal|
|00005080| 20 72 65 73 74 69 6e 67 | 20 50 61 4f 32 2c 20 6f | resting| PaO2, o|
|00005090| 78 79 67 65 6e 20 73 61 | 74 75 72 61 74 69 6f 6e |xygen sa|turation|
|000050a0| 0d 0a 66 65 6c 6c 20 74 | 6f 20 39 30 25 20 6f 72 |..fell t|o 90% or|
|000050b0| 20 6c 65 73 73 20 61 66 | 74 65 72 20 31 30 20 6d | less af|ter 10 m|
|000050c0| 69 6e 75 74 65 73 20 6f | 66 20 65 78 65 72 63 69 |inutes o|f exerci|
|000050d0| 73 65 2e 20 20 48 6f 77 | 65 76 65 72 2c 20 69 6e |se. How|ever, in|
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|00005e50| 6d 20 52 65 73 6f 75 72 | 63 65 73 20 49 6e 63 2c |m Resour|ces Inc,|
|00005e60| 20 46 72 65 64 65 72 69 | 63 6b 2c 20 4d 64 29 0d | Frederi|ck, Md).|
|00005e70| 0a 41 6e 6e 20 49 6e 74 | 65 72 6e 20 4d 65 64 20 |.Ann Int|ern Med |
|00005e80| 31 31 31 3a 32 32 33 2d | 32 33 31 2c 20 41 75 67 |111:223-|231, Aug|
|00005e90| 20 31 2c 20 31 39 38 39 | 0d 0a 2d 2d 2d 2d 2d 2d | 1, 1989|..------|
|00005ea0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005eb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005ec0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005ed0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005ee0| 2d 2d 2d 2d 2d 2d 2d 2d | 0d 0a 0d 0a 50 72 65 2d |--------|....Pre-|
|00005ef0| 43 6f 6d 6d 65 6e 74 0d | 0a 0d 0a 20 20 20 20 20 |Comment.|... |
|00005f00| 54 68 65 20 6e 65 78 74 | 20 70 61 70 65 72 20 62 |The next| paper b|
|00005f10| 79 20 4d 61 73 75 72 20 | 61 6e 64 20 61 73 73 6f |y Masur |and asso|
|00005f20| 63 69 61 74 65 73 20 63 | 6f 6e 74 69 6e 75 65 73 |ciates c|ontinues|
|00005f30| 20 74 68 65 20 74 68 65 | 6d 65 20 74 68 61 74 20 | the the|me that |
|00005f40| 72 69 73 6b 20 66 6f 72 | 0d 0a 50 6e 65 75 6d 6f |risk for|..Pneumo|
|00005f50| 63 79 73 74 69 73 20 69 | 6e 66 65 63 74 69 6f 6e |cystis i|nfection|
|00005f60| 20 69 6e 20 48 49 56 2d | 70 6f 73 69 74 69 76 65 | in HIV-|positive|
|00005f70| 20 70 65 72 73 6f 6e 73 | 20 6d 61 79 20 62 65 20 | persons| may be |
|00005f80| 69 64 65 6e 74 69 66 69 | 65 64 20 62 79 20 63 68 |identifi|ed by ch|
|00005f90| 61 6e 67 65 73 20 69 6e | 0d 0a 70 68 79 73 69 6f |anges in|..physio|
|00005fa0| 6c 6f 67 69 63 20 70 61 | 72 61 6d 65 74 65 72 73 |logic pa|rameters|
|00005fb0| 2c 20 69 6e 20 74 68 69 | 73 20 63 61 73 65 20 74 |, in thi|s case t|
|00005fc0| 68 65 20 43 44 34 2b 20 | 6c 79 6d 70 68 6f 63 79 |he CD4+ |lymphocy|
|00005fd0| 74 65 20 63 65 6c 6c 20 | 63 6f 75 6e 74 2e 0d 0a |te cell |count...|
|00005fe0| 52 65 74 72 6f 73 70 65 | 63 74 69 76 65 6c 79 20 |Retrospe|ctively |
|00005ff0| 73 74 75 64 69 65 64 20 | 70 61 74 69 65 6e 74 73 |studied |patients|
|00006000| 20 77 69 74 68 20 70 75 | 6c 6d 6f 6e 61 72 79 20 | with pu|lmonary |
|00006010| 69 6e 66 65 63 74 69 6f | 6e 20 6f 72 20 4b 61 70 |infectio|n or Kap|
|00006020| 6f 73 69 27 73 20 73 61 | 72 63 6f 6d 61 0d 0a 68 |osi's sa|rcoma..h|
|00006030| 61 64 20 61 20 43 34 2f | 50 44 34 20 6c 79 6d 70 |ad a C4/|PD4 lymp|
|00006040| 68 6f 63 79 74 65 20 63 | 6f 75 6e 74 20 6f 66 20 |hocyte c|ount of |
|00006050| 6c 65 73 73 20 74 68 61 | 6e 20 32 30 30 20 63 65 |less tha|n 200 ce|
|00006060| 6c 6c 73 2f 6d 6d 5e 33 | 20 77 69 74 68 69 6e 20 |lls/mm^3| within |
|00006070| 36 30 20 64 61 79 73 20 | 6f 66 0d 0a 74 68 65 20 |60 days |of..the |
|00006080| 65 70 69 73 6f 64 65 2e | 20 20 54 68 69 73 20 63 |episode.| This c|
|00006090| 6f 6e 63 6c 75 73 69 6f | 6e 20 72 65 71 75 69 72 |onclusio|n requir|
|000060a0| 65 73 20 63 6f 6e 66 69 | 72 6d 61 74 69 6f 6e 20 |es confi|rmation |
|000060b0| 69 6e 20 61 20 70 72 6f | 73 70 65 63 74 69 76 65 |in a pro|spective|
|000060c0| 20 73 74 75 64 79 2c 0d | 0a 62 75 74 20 69 74 20 | study,.|.but it |
|000060d0| 69 73 20 63 6f 6e 73 69 | 73 74 65 6e 74 20 77 69 |is consi|stent wi|
|000060e0| 74 68 20 74 68 65 20 49 | 67 4d 20 66 69 6e 64 69 |th the I|gM findi|
|000060f0| 6e 67 73 20 72 65 70 6f | 72 74 65 64 20 69 6e 20 |ngs repo|rted in |
|00006100| 74 68 65 20 70 72 65 76 | 69 6f 75 73 20 70 61 70 |the prev|ious pap|
|00006110| 65 72 2e 0d 0a 57 68 61 | 74 20 69 73 20 75 6e 63 |er...Wha|t is unc|
|00006120| 6c 65 61 72 20 69 73 20 | 77 68 65 74 68 65 72 20 |lear is |whether |
|00006130| 74 68 65 20 69 6d 6d 75 | 6e 6f 6c 6f 67 69 63 20 |the immu|nologic |
|00006140| 64 65 63 6c 69 6e 65 20 | 70 72 65 63 65 64 65 73 |decline |precedes|
|00006150| 20 61 6e 64 20 63 61 75 | 73 65 73 2c 20 6f 72 20 | and cau|ses, or |
|00006160| 69 73 0d 0a 61 20 63 6f | 6d 70 6f 6e 65 6e 74 20 |is..a co|mponent |
|00006170| 6f 66 2c 20 74 68 65 20 | 73 75 62 73 65 71 75 65 |of, the |subseque|
|00006180| 6e 74 20 70 75 6c 6d 6f | 6e 61 72 79 20 69 6e 66 |nt pulmo|nary inf|
|00006190| 65 63 74 69 6f 6e 2e 2d | 2d 47 2e 4d 2e 20 47 72 |ection.-|-G.M. Gr|
|000061a0| 65 65 6e 2c 20 4d 2e 44 | 2e 0d 0a 0d 0a 41 62 73 |een, M.D|.....Abs|
|000061b0| 74 72 61 63 74 0d 0a 0d | 0a 20 20 20 20 20 4f 70 |tract...|. Op|
|000061c0| 70 6f 72 74 75 6e 69 73 | 74 69 63 20 69 6e 66 65 |portunis|tic infe|
|000061d0| 63 74 69 6f 6e 73 20 69 | 6e 20 70 61 74 69 65 6e |ctions i|n patien|
|000061e0| 74 73 20 69 6e 66 65 63 | 74 65 64 20 62 79 20 48 |ts infec|ted by H|
|000061f0| 49 56 20 72 65 73 75 6c | 74 20 64 69 72 65 63 74 |IV resul|t direct|
|00006200| 6c 79 20 66 72 6f 6d 0d | 0a 64 65 70 6c 65 74 69 |ly from.|.depleti|
|00006210| 6f 6e 20 6f 66 20 43 44 | 34 20 63 65 6c 6c 73 2e |on of CD|4 cells.|
|00006220| 20 20 46 75 72 74 68 65 | 72 20 6b 6e 6f 77 6c 65 | Furthe|r knowle|
|00006230| 64 67 65 20 6f 66 20 74 | 68 65 20 63 6f 75 72 73 |dge of t|he cours|
|00006240| 65 20 6f 66 20 74 68 65 | 73 65 20 69 6e 66 65 63 |e of the|se infec|
|00006250| 74 69 6f 6e 73 0d 0a 6d | 69 67 68 74 20 61 6c 6c |tions..m|ight all|
|00006260| 6f 77 20 74 69 6d 65 6c | 79 20 61 6e 64 20 63 6f |ow timel|y and co|
|00006270| 73 74 2d 65 66 66 65 63 | 74 69 76 65 20 70 72 6f |st-effec|tive pro|
|00006280| 70 68 79 6c 61 78 69 73 | 2e 20 20 54 68 65 20 70 |phylaxis|. The p|
|00006290| 72 65 64 69 63 74 69 76 | 65 20 76 61 6c 75 65 20 |redictiv|e value |
|000062a0| 6f 66 0d 0a 63 69 72 63 | 75 6c 61 74 69 6e 67 20 |of..circ|ulating |
|000062b0| 43 44 34 2b 20 6c 79 6d | 70 68 6f 63 79 74 65 20 |CD4+ lym|phocyte |
|000062c0| 63 6f 75 6e 74 73 20 77 | 61 73 20 65 78 61 6d 69 |counts w|as exami|
|000062d0| 6e 65 64 20 69 6e 20 31 | 30 30 20 70 61 74 69 65 |ned in 1|00 patie|
|000062e0| 6e 74 73 20 77 69 74 68 | 20 48 49 56 0d 0a 69 6e |nts with| HIV..in|
|000062f0| 66 65 63 74 69 6f 6e 20 | 77 68 6f 20 68 61 64 20 |fection |who had |
|00006300| 31 31 39 20 65 70 69 73 | 6f 64 65 73 20 6f 66 20 |119 epis|odes of |
|00006310| 70 75 6c 6d 6f 6e 61 72 | 79 20 64 79 73 66 75 6e |pulmonar|y dysfun|
|00006320| 63 74 69 6f 6e 20 77 69 | 74 68 69 6e 20 32 20 6d |ction wi|thin 2 m|
|00006330| 6f 6e 74 68 73 20 6f 66 | 20 43 44 34 0d 0a 6c 79 |onths of| CD4..ly|
|00006340| 6d 70 68 6f 63 79 74 65 | 20 65 73 74 69 6d 61 74 |mphocyte| estimat|
|00006350| 69 6f 6e 2e 0d 0a 20 20 | 20 20 20 43 69 72 63 75 |ion... | Circu|
|00006360| 6c 61 74 69 6e 67 20 43 | 44 34 20 63 65 6c 6c 20 |lating C|D4 cell |
|00006370| 63 6f 75 6e 74 73 20 77 | 65 72 65 20 6c 65 73 73 |counts w|ere less|
|00006380| 20 74 68 61 6e 20 30 2e | 32 20 78 20 31 30 5e 39 | than 0.|2 x 10^9|
|00006390| 20 63 65 6c 6c 73 2f 4c | 20 28 32 30 30 0d 0a 63 | cells/L| (200..c|
|000063a0| 65 6c 6c 73 2f 6d 6d 5e | 33 29 20 62 65 66 6f 72 |ells/mm^|3) befor|
|000063b0| 65 20 34 36 20 6f 66 20 | 34 39 20 65 70 69 73 6f |e 46 of |49 episo|
|000063c0| 64 65 73 20 6f 66 20 50 | 6e 65 75 6d 6f 63 79 73 |des of P|neumocys|
|000063d0| 74 69 73 20 70 6e 65 75 | 6d 6f 6e 69 61 2c 20 61 |tis pneu|monia, a|
|000063e0| 6c 6c 20 38 20 65 70 69 | 73 6f 64 65 73 0d 0a 6f |ll 8 epi|sodes..o|
|000063f0| 66 20 63 79 74 6f 6d 65 | 67 61 6c 6f 76 69 72 75 |f cytome|galoviru|
+--------+-------------------------+-------------------------+--------+--------+
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